Celery Seed Extract And Gout

celery good for gout

Is Celery Good For Gout?

The plant known as celery (Apium graveolens) is commonly eaten raw or cooked as a vegetable. The seed is utilized as a spice in cooking. 

But did you know that celery seed extract has been found to possess similar properties as aspirin, ibuprofen and naproxen in reducing inflammation in gout patients? 

These compounds have been researched for their role in inflammation and uric acid production via purines, which is a driving force behind the severity of gout flare ups.

Help For Gout

Gout sufferers have a 25% higher premature death risk than people without the condition according to Arthritis Foundation.

Gout is a severe form of arthritis that develops when uric acid crystallizes and deposits in the joints. These symptoms include:

  • Inflammation 
  • Stiffness in joints
  • Severe pain 

The gout relieving compounds found in celery seed extract are:

  • Luteolin
  • 3.n-butylphthalide (3nB)
  • Beta-selinene

Luteolin in celery seed extract is a compound that lowers harmful uric acid levels by inhibiting the activity of two proteins associated with gout, the enzyme xanthine oxidase and the protein NF-κB. These two proteins are believed to play an important role in the pathogenesis of gout.

Beta-selinene and 3-n-butylphthalide (3nB) have a variety of anti-inflammatory and antioxidant properties that may be useful in lowering gout inflammation. 

Beta-selinene in celery seed extract works by reducing inflammation, inhibiting the production of uric acid, and reducing oxidative stress. It may also help reduce the pain associated with gout symptoms.

3-n-butylphthalide works by decreasing inflammation, improving joint function, and eliminating uric acid from the body.

Clinical Evidence For Celery Seed Extract As Gout Relief

Different studies demonstrate the benefits of celery seed extract for gout;

  • According to a study in 2015, celery seed may aid patients who suffer from certain inflammatory disorders, such as gout and ulcers, by reducing pain and inflammation. 
  • According to research published in the Journal Progress in Drug Research in 2015, celery seed extract may be able to relieve inflammation almost as effectively as aspirin and ibuprofen.
  • A 12-week study was carried out in 15 patients with either OA, osteoporosis or gout. The patients received 34 mg of celery extract twice daily. The study found that after 3 weeks of the treatment, the average reduction in pain scores was 68%, with 100% pain relief in some patients. Maximum benefit was observed in patients who continued treatment for 6 weeks. 
  • In a study conducted at the Gout Research Center in Taiwan, participants taking celery seed extract experienced a significant decrease in gout symptoms. The study also revealed that celery seed extract was associated with improved joint function, as well as a reduction in inflammation and oxidative stress.

Additional Benefits Of Celery Seed Extract

There are many other benefits of celery seed extract other than it relieving gout pain.

Here are a few below;

Lose Weight

Celery seeds are loaded with nutrients, especially calcium, manganese, and iron that aid in weight loss, liver detoxification, and increased lipid metabolism. They offer almost equal quantities of carbohydrates, protein, and fat while being low in calories.

Enhance cognitive performance

The iron content of celery seeds enhances the formation of hemoglobin and blood flow. Increased cognitive function and a decline in cognitive illnesses like Alzheimer’s disease and dementia are both correlated with adequate levels of oxygen and iron in the brain.

Cancer Prevention 

Celery seed extract may also aid in the battle against stomach cancer by activating apoptosis, according to a 2011 study on human cells that was published in the Asian Pacific Journal of Cancer Prevention.

Encourage Bone health

Calcium is one of the most well-known nutrients for healthy bones. It is present in celery seed extract. Increasing your calcium intake may lower your risk of fractures, according to research. 

Production Of Red Blood Cells

There is plenty of iron in celery seeds. Consuming more foods high in iron has been demonstrated to reduce your risk of anemia. 

Reduce Blood Pressure 

In preliminary research, 75 mg of celery seed extract was administered twice daily to 30 participants with moderately high blood pressure. After a few weeks of supplementation, blood pressure started to decline; at the end of six weeks, it had, on average, dropped from 139/85 to 131/76.

Lower Blood Sugar Level

Magnesium helps your cells respond more quickly to the hormone insulin, which controls blood sugar levels. Consuming foods high in magnesium, such as celery seeds, may lower the 14% chance of developing type 2 Diabetes.

Avoid Ulcers

A special ethanol extract found in celery inhibits the growth of stomach ulcers. To prevent the lining of the digestive tract from being damaged by tiny holes and openings, celery seed extract restores depleted levels of gastric mucus. 

Might Combat Bacteria

Celery seed has a long history of use as a digestive aid and recent studies have revealed its antimicrobial qualities. According to laboratory tests, it prevents H. pylori bacteria, which can lead to stomach ulcers.

Side Effects 

Celery seed extract in large doses may cause:

  • Skin inflammation 
  • Celery seed extract may also interact with a variety of drugs, including thyroid medication, diuretics, and blood thinners. 
  • Uterine hemorrhage and uterine muscle spasms of which might raise the chance of miscarriage in pregnant women according to Pharmacognosy  Review in June 2017.

Conclusion

Celery seed extract possesses several ingredients that help in gout flare ups.

It’s one of only a few natural gout treatments that has been proven to work.

Luteolin lowers uric acid levels and Beta-selinene and 3-n-butylphthalide both possess antioxidant and anti-inflammatory effects.

Whilst most studies have been on animals, there have been clinical trials involving humans too so;

Our Goutometer gives it a 6/10.

It looks very promising but I’d slightly lean towards turmeric or tart cherry supplements where there have been more human medical trials for gout relief.

In general, celery seeds are safe to consume, but excessive amounts might cause serious responses.

Because of this, you should speak with a doctor before adding celery seed extract to your diet, especially if you are expecting, breastfeeding, or on any prescription drugs. 

Free eBook ->

A full A-Z Purine Chart revealing what foods are good for gout and what foods are bad. You may be surprised!

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References

  • Gao, L. L., Feng, L., Yao, S. T., Jiao, P., Qin, S. C., Zhang, W., Zhang, Y. B., & Li, F. R. (2011). Molecular mechanisms of celery seed extract induced apoptosis via s phase cell cycle arrest in the BGC-823 human stomach cancer cell line. Asian Pacific journal of cancer prevention: APJCP, 12(10), 2601–2606.
  • Office of the Surgeon General (US). Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville (MD): Office of the Surgeon General (US); 2004. 6, Determinants of Bone Health. Available from: https://www.ncbi.nlm.nih.gov/books/NBK45503/
  • Aspuru, K., Villa, C., Bermejo, F., Herrero, P., & López, S. G. (2011). Optimal management of iron deficiency anemia due to poor dietary intake. International journal of general medicine, 4, 741–750. https://doi.org/10.2147/IJGM.S17788
  • Dong, J. Y., Xun, P., He, K., & Qin, L. Q. (2011). Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies. Diabetes care, 34(9), 2116–2122. https://doi.org/10.2337/dc11-0518
  • Zhou, Y., Taylor, B., Smith, T. J., Liu, Z. P., Clench, M., Davies, N. W., & Rainsford, K. D. (2009). A novel compound from celery seed with a bactericidal effect against Helicobacter pylori. The Journal of pharmacy and pharmacology, 61(8), 1067–1077. https://doi.org/10.1211/jpp/61.08.0011
  • Ciganda, C., & Laborde, A. (2003). Herbal infusions used for induced abortion. Journal of toxicology. Clinical toxicology, 41(3), 235–239. https://doi.org/10.1081/clt-120021104
  • Powanda, M. C., Whitehouse, M. W., & Rainsford, K. D. (2015). Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 70, 133–153. https://doi.org/10.1007/978-3-0348-0927-6_4
  • Ding, Y., Shi, X., Shuai, X., Xu, Y., Liu, Y., Liang, X., Wei, D., & Su, D. (2014). Luteolin prevents uric acid-induced pancreatic β-cell dysfunction. Journal of biomedical research, 28(4), 292–298. https://doi.org/10.7555/JBR.28.20130170
  • Liu CY, Zhao ZH, Chen ZT, Che CH, Zou ZY, Wu XM, Chen SG, Li YX, Lin HB, Wei XF, You J, Huang HP. DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses. Exp Ther Med. 2017 Sep;14(3):2241-2248. doi: 10.3892/etm.2017.4784. Epub 2017 Jul 12. PMID: 28962149; PMCID: PMC5609149.
  • Cobb, C. S., & Ernst, E. (2006). Systematic review of a marine nutriceutical supplement in clinical trials for arthritis: the effectiveness of the New Zealand green-lipped mussel Perna canaliculus. Clinical rheumatology, 25(3), 275–284. https://doi.org/10.1007/s10067-005-0001-8